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KMID : 0377619720230010033
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Korean Jungang Medical Journal
1972 Volume.23 No. 1 p.33 ~ p.40
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MECHANISM OF DEPRESSANT ACTION OF INHALATION ANESTHETICS ON THE HEART
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Ko, Kye-Chang/高啓昌
Jung, Jee Chang/Han, Dae Sup/鄭址昌/韓大燮
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Abstract
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Certain metabolic aspects of halothane´s ,cardiac depressant action on the contractility of the myocardium were elucidated from a study of the effect of pyruvate on halothane-depressed rat atria. Approximately 6mg% halothane was required to maintain a 50% depression of the contractility of rat atria :suspended in a modified Krebs-Ringer bicarbonate glucose medium, pH 7.4, 30°C for a 2 hr.period. Pyruvate was found to restore partially the contractility of halothanedepressed atria. The maximally effective concentration of pyruvate was 2.5mM. There was minimal pyruvate effect on the force of contraction of control atria. The effect of pyruvate on halothahe- depressed .,atria was shown to be due to the pyruvate and not the sodium ion of the sodium pyruvate.
Pyruvate was found to produce no increase in the contractility of atria depressed by hypertonic medium, but caused a further depression. Selected aspects regarding the myocardial cells are discussed. The results are consistent with the hypothesis that at least a part of the negative inotropic action of halothane is due to an inhibition of glucose uptake or utilization in the glycolytic pathway.
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KEYWORD
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